you look at what’s going on at the level of science it’s clear that the science has gotten way ahead of the manufacturing when it comes to cells tissues and [Music] organs if any of you know somebody waiting for a transplant of any kind of organ even hearts in particular it’s a long terrifying wait for a typical adult think about a baby or a small child that needs one of these organs you really want some other baby or small child to have to die we shouldn’t have to wait for people to die in order to let somebody live we got to stop this there’s no equivalent of Silicon Valley that will bring the engineering community the manufacturing Community to the world of science we’re going to make it practical to manufacture High quantity high quality reasonable price cells tissues and organs let’s actually begin with the
[00:01:00] story of these ibots and then I want to get into some of the extraordinary moonshots you’re in the midst of so a long time ago in a far away Place uh we decided that a wheelchair which has been the standard of care since actually Benjamin Franklin another inventor you know bifocals other medical inventions Ben Franklin 200 years ago patented a wheelchair he should have been proud of it at after 200 years we can build machines that go to the moon planets we have machines that could put people everywhere under the sea but until I started building this standard of care for people that couldn’t walk it’s a wheelchair if any of you have ever had to use one even for a day or a week you’ll know what a pathetic alternative that is and it’s not just about mobility and I knew that when we
[00:02:00] started building these things when somebody is confined to a wheelchair and by the way confined is a common phrase for that the only other place I always hear the word confined is if somebody is so evil we confine them to prison I don’t think a vet that comes back from leaving his legs in Afghanistan and an IED or should be confined to a wheelchair and I realized since I build helicopters and autopilots and all sorts of things why don’t we take solid state Gyros and accelerometers and high performance control systems and build something that simulates human balance everybody in this room has a mom that remembers two things about you as a little kid your first words and your first steps they’re uniquely human we walk erct and when somebody loses the ability for any reason disease accidents when you lose the ability to
[00:03:01] stand up it’s not about Mobility yes this thing climbs curbs and stairs and goes through sand we’ll show you a video of that but but you don’t spend much of your day climbing stairs but you spend most of your time interfacing with your colleagues your family your husband your wife your kids and to do that from a confined position you didn’t lose Mobility you lost dignity you lost access you lost Independence so we decided we’ll fix that and we did did we took it to the FDA yeah we took it to the FDA and they said you know we approve products based on benefit and risk you know you got gleo blastoma we know what the outcome’s going to be we’ll try anything and they approved drugs that have three pages of small print about what it might do to you but the risk and benefit are there we took this to the FDA and they said we won’t even accept a proposal
[00:04:00] to review that thing because wheelchairs are safe and there’s no benefit I had to convince people at the FDA they ought to try living in a wheelchair for a while uh we ended up uh compromising and doing it my way and we know that theme song here and uh and we submitted it I pointed out it would be triply redundant no single failure of a component a syst system a power supply a processor a gy a gyroscope there’s multiples of them I said we will not build a system that any single point failure will bring this thing down we put some out there and after the fleet collected slightly over 10 million hours of operation in the field with real people not a single system had ever gone down we went back to the FDA and said we want to take us out of class three put us back into class two so we can start making units for p atric patients and
[00:05:00] for others and uh probably in the history as I know of the FDA moving down a category from the most severe class three into class two Based on data we got that change we got this thing into class two we built a new generation of them we just recently in January after only 16 years got CMS medicare and medicaid to say yes we recognize that there’s a need for this and they’re putting it on their list the Veterans Administration the Veterans Administration has accepted 50 of them I donated two to each of the 25 VA hospitals that take care of our vets and uh I hope they’re going to start letting vets have a better quality of life we have a I think a one minute video that shows this thing running around if you want to see well I wanted so this is amazing as is your luk arm as is your slingshot as is a th of your inventions
[00:06:01] and we can play this in in background mode um if you want yeah there’s no audio play it but there ask yourselves as you look at this do you know anybody that lives in a wheelchair that can do that go ahead play it that’s New Hampshire by the way for you people in California that’s water in its solid [Laughter] F so we’re we decided out of your 100 plus moonshots that we would focus on on three of them um one is the work that you’re doing at army the advanced regenerative manufacturing Institute which follows on on the longevity work this morning um yay amazing off-road I drove one of these up the stairs at the Eiffel Tower into the juwes ver restaurant everybody else was
[00:07:01] using an elevator who would have thought it only you buddy so we’re going to talk about Army we’re going to talk about Daisy and we’re going to talk about of course first first but we’ll talk about first last because I know that once we start on first it’s the last topic we’ll talk about and we have a lot to say about that we have a lot to say yes so um we’ve talked about this before and those those of you who have been on the Platinum longevity trip every time we’re on the East Coast we have the pleasure of going to the uh Army facilities in New Hampshire these old Loom factories turned now into organ manufacturing facilities and I remember we went there 3 years ago there like little room and now we went back and you had just taken over these facilities so what is Army
[00:08:00] Army stands for advanced regenerative manufacturing Institute uh you’ve had a number of speakers talk around it and about it in fact Nina Tandon who you just had up here is is a member and we’ve been helping her turn her dreams into reality and Martine rothblat has been on the stage before she’s one of my founding board members of Army and we can show you some of the stuff we’re doing with her she is now in our Millard taken over an 880,000 square foot building and that entire building is now dedicated to manufacturing manufacturing lungs and kidneys it’s the first place on planet Earth that’s doing that um we will be in clinical trials with a half a dozen different Army based products within the next so what was the what was the the moonshot set for you in in this it was initially funded by the government and and is still today and by the way not that I think there’s fate here but three
[00:09:00] incredible things have happened to me after I touched down in California yesterday yesterday um I got a call that apparently the FDA has issued on their website the fact that they just approved our closed loop insulin pump with no moving Parts connected to sensors and has full onboard software to do essentially artificial an artificial pancreas to sense your blood glucose level and pump in insulin no more finger Pricks no more ups and downs took enough time yeah that was only about 10 years in the making it’s another one of my instant overnight successes so um I also found out this morning 6:00 hour time here they didn’t know where I was when I got the call at 6 o’ that after a whole bunch of work we done in a couple of reviews and you’ll see some slides of some people why if we show them that Army just
[00:10:00] got official confirmation of aund million new Grant coming additional Grant additional Grant bring to what level of total Capital now well over 200 million now and I thought when they gave us the first 80 million when we started this thing about six years ago I was at a press conference at the White House and I told him at the time we’re going to figure out how to make it practical to take all the the Miracles of science being generated in all the med schools and all the like you just heard people like like Michael Levan you’ve heard people like you know well you bring them all here I don’t have to tell you um but you you look at what’s going on at the level of Science and like Daniel craft and and by the way I apologize I can’t possibly project as efficiently as your speakers who especially since I don’t even know what you’re can ask me but but we looked back then and said it’s clear that the
[00:11:01] science has gotten way ahead of the manufacturing when it comes to cells tissues and organs uh every other industry you know they they won the Nobel Prize in the late 40s and 50s at Bell labs for figuring how to make a transistor but within a decade there was Silicon Valley and an infrastructure to to build the digital world that we know of 100 years before that you know the first cars became obviously uh a real deal and Detroit built an infrastructure Iron and Steel and castings and forgings and gears and well all the different Med schools all the different research institutions had Petri dishes you heard Nina talk about it and Petri dishes and and pipets and slave labor like postto and grad students that will do all of this work but there’s no industry there’s no equivalent of Silicon Valley that will bring the engineering community the manufacturing Community to the world of science so we told the government uh we’re going to make it
[00:12:00] practical to manufacture High quantity high quality reasonable price cells tissues and organs and I’ve been building dialysis equipment for 30 years and there’s 200,000 people waiting for their kidney transplants and 20% are dying every year and the list gets longer not shorter um same thing with waiting for eyelid cells or a pancreas people that are waiting for a liver don’t have the equivalent of dialysis so if they’re not on that list and lucky enough to get a cavic uh liver quickly they die people are waiting for lungs so we said we got to stop this and we shouldn’t have to wait for people to die in order to let somebody live let’s just remanufacture organs and we also said to them right up front we’ll use the ipscs the induced plur poent stem cells out of the patient that you know will be the recipient to be the cells we put into the printed or by any other means manufactured uh in infrastructure of so
[00:13:00] it’s not any organ it’s your organ it’s your organ and by the way in that same press conference I said to the folks at the white house uh even if we’re lucky enough that within the five years I told you we’ll get something in front of the FDA we don’t even know how they’re going to be able to evaluate it because everything they do at the FDA is it’s of course appropriately statistical you know if you’re going to make 12 billion of these pills prove that they’re the same I said we’re going to show up at the FDA and say yeah we’re making organs and by the way even though we’re going to make 100,000 kidneys we hope in the first year we get out there with them each kidney is going to be very specifically different each kidney is going to have the DNA of the intended recipient and it’s going to pop out of the oven nice and warm it’s going to be immediately whisked into a surgical field handed to a surgeon who’s going to zip it into the patient and they go home sorry FDA there’s no way you can be in the middle of that process QA for that person yeah and so so we said to them I said in the White House unless we start
[00:14:00] now we’ll be five years ahead of the FDA when we have the capacity to do this um they’re going to need to come up with a complete regulatory strategy to make this possible the first full-time employee of army I called it Army in respect for the dod it wasn’t by the way HHS or it wasn’t all the places you’d think that we get Healthcare funded National Science F no it was the Department of Defense that gave us the money because they said Dean we need skin we need bone we need this stuff so I’m down in Washington we tell that story and I said the FDA is going to be the biggest uncertainty in this whole thing I’m sure the scientists will deliver the recipe to make cells tissues and organs I’m sure we’re going to find a way to do high volume manufacturing to get consistent quality and outcomes and document the thing but how are we going to get it approved a guy that spent 18 years mdphd at FDA rising to being the policy director at the Cur the one-third of the FDA that’s on that resigned that
[00:15:00] day and moved up to New Hampshire coincidence coincidence I told him he should resign get to our side of the table and help us prepare to help the FDA partner with us to get these things approved so so Dr Richard McFarland became the first full-time employee of army I then said we need standards so we went down to Washington we plucked a few folks out of NIS the National Institute for standard and Technology we got them on board Army now has 200 member organizations most of the big Med schools some of the big Pharma companies a lot of little startups um and it has uh probably about 60 full-time employees across all the disciplines necessary let organs let me make this palpable for folks so we’re talking about uh if you should need a backup let’s list some organs here first of all you know bone ligament bone the work that Nina is doing skin uh a kidney kidney is a very very
[00:16:03] and and livers and lungs but we now have a little one that’s about to go in front of the FDA think about this people most of you hope to live long we’ve heard all about longevity we already know that something that was once considered rare as becoming quite an appropriate fear among people getting older and that’s macular degeneration well instead of building the entire kidney what if you could make something that’s about oh a couple of millimet by a couple of millimeters and you could slip it in almost nonsurgically uh attached to a retina to give somebody essentially their own brand new healthy ability to see we have now built a device that’s spitting those things out we’re testing them in animals but I’m believing that within certainly a couple of years that will be in front of the FDA and your worries about mular degeneration may be substantially reduced
[00:17:00] um pancreatic eyelid cells so regrow some pancreas so I started 40 years ago when my brother was still in med school and I built for him little pumps that were used to deliver the first insulin for diab for diabetes a long time went by and I only started making these solid state ones when it started a decade ago to become clear that we could build cloes Loop control systems with reliable glucose sensors and I’ll show you something in a minute about that if you ask but but it turned out that nobody wants to deal with insulin whether it’s in a pump or not I mean we’ve gotten a lot better nobody wants to wear cgms and your six-year-old daughter or granddaughter shouldn’t have to be careful about having that ice cream cake at that birthday party so we’ve been saying for a long time let’s just make new eyelet cells new beta cells let’s make a pancreas I’ve have been working with JDRF one of the most prestigious organizations for dealing with this issue issue for 30 years CU I
[00:18:01] started making pumps with them and the only thing I used to know about JDRF was every year they have a big fundraiser every year I go we we like everybody else write checks to them last year when they came up and saw the scale of what we were doing in the bio reactors we were building the JDRF came to us and said we’d like to give you guys a few million bucks so that you can start building massive quantities of eyelet cells so that we can give those to every researcher that we now fund around the country so instead of spending a an enormous percentage of the money we give them for research where they’re essentially building their own tools before they get to do their work it solves two problems for them if every different University or research organization has to make their own island of beta cells from their own St you know Parts the variability is so large that nobody’s even going to believe it’s something you could duplicate which is why medical journals write papers and half the paper is about you know what did we do and every every body else tries to duplicate it and they
[00:19:00] typically can’t JDRF said to us let’s make standard line of cells we’ll give them to everybody then they can spend all their time and all their money on their version of their solution and the example to you would be is if you had builders in every community and you all want them to build you a house but if every Builder after they you approved you know what they’re going to build for you they had to go out and make their own Hammers and make their own nails and manufacture their own tools no way so JDRF did that the night the reason I couldn’t come out for the first day yesterday is the entire Board of JDRF and a lot of their major found funders and recipients showed up at my house for a celebration dinner night before last where we announced to them and showed them a couple of bioreactors that are making a few billion eyet cells per day at this point point two billion isid cells per day and we’re starting to within the next few months we’ll be shipping some of them around the country
[00:20:02] yeah and you can make hearts yeah this is over a year old now and this is darus Taylor’s heart that was a decellularized and then recellularized tiny pig that heart is the right size to transplant into a baby if any of you know somebody waiting for a transplant of any kind of organ even hearts in particular it’s a long terrifying wait for a typical adult but but frankly most of the cavic organs that are available are adults some idiot kid gets drunk drives his motorcycle into a tree well you get a bunch of good organs but they’re typically adult size think about a baby yeah or a small child that needs one of these organs you really want some other baby a small child to have to die so we said let’s start making pediatric size Hearts uh this thing is reinfused with some ipscs and you saw it it it it pumps amazing uh we will be uh
[00:21:01] we will be putting some of these quote manufactured hearts in animals this year um I remember having a conversation with with Elon about Mass about manufacturing and the comment he made was so aute and it applies to everything you’re doing here he said if you have the ratio of the value of the invention idea relative to the difficulty of productionizing and Mass manufacturing it basically is like one to Infinity that the ability to actually go into production and produce this and and you’re actually building you’re taking over all of those buildings and what’s your vision a decade from now what’s what’s this New Hampshire facility going to look like again I’ll be able to show you a slide of that um the Old Mills he’s referring to I can show a picture of this but that Mill the amamos Mills was the largest single
[00:22:00] operating industrial complex in the world at the time they had 22,000 waterp powerered Looms in there and that were producing a massive amount of the worlds then advanced technology uh knitting uh uh textiles after the Great Depression they pretty much closed that stuff became a commodity that milard was virtually empty when I moved up there 40 years ago from New York I moved into the very smallest building right in the middle there the white one with a white roof next to to the one that’s ag- shaped um those are all white cuz I had to put rots on them now every one of those things shows either one of my Deca companies one of the army companies first our University affiliation to train kids to become the next industry but that’s now we have a couple of million square feet and we told everybody and I told you this years ago if Army works it’s not a product it’s not one organ it’s not one company it’s an industry this is the birth what what Silicon Valley did once we understood
[00:23:01] semiconductor technology this is going to be the epicenter of an industry to make it practical to manufacture human cells tissues and organs so I said we’ll call they got Silicon Valley we’ll call ours Carbon Valley on the East Coast we’re carbon based people said to me Dean don’t use the word carbon okay so we’ll be regen valleys so we started calling this region Valley and just a few months ago uh when we were told we might get the next 100 million oh started to say after 3 years I was a little nervous and it was harder than we thought and I had burned through a lot of the 80 million and I thought they might not be happy when the dod the assistant Secretary of Defense vice president president they all came up they were so blown away by how fast we were moving by the way that’s both of my Senators Shaheen and and Asen our mayor of our city and G romondo the secretary at compers a few months ago when the president of the United States Biden asked everybody to be there when he went
[00:24:00] broadcasting from uh the Oval Office the fact that they have officially through Eda The Economic Development Authority announced this is the president’s words that the Manchester milliard is now the epicenter of regen Valley for the United States and the world so can we just take a second and just appreciate that so I I’m imagining a decade a a a centralized Factory facility where ahead of your need of a of an organ a skin sample is taken it’s converted to an induced plop potent stem cell it’s put in one end of your bioreactor it’s multiplied some tens of billions of times differentiated appropriately and out the other end comes a functioning organ is that does that did I get it correct you got it exactly right and in fact to make sure that freshly baked right out of the oven they’re not going to have that long a life so separate from Army which is this in that same massive
[00:25:02] building that they’re standing in I put a little Outpost of deca that’s building a thing that we call the Pod there may be a picture of that and that pod is a life support system for the or past trip yeah and we now have taken cavar kidneys for instance that typically after three or four hours no surgeon would put them in somebody after four days of putting it in this little thing which by the way is now on Wheels and we roll it around the ENT High campus just to prove uh it has onboard electric power but it has nitrogen it has oxygen it has CO2 it has and it’s on Wheels and we’re driving it around and after four days that thing which is full of sensor technology that’s measuring the kidney that we put in there is making more urine than when we took it out of the kadaba it’s in Better Health than it was and now we’re working as you know with Martine Roth platen beta to build a vertiport by which it will be put uh into one of our vertical takeoff machines it will be
[00:26:00] flown uh either to a local hospital one of the local ones like Harvard or you know where’re we’re halfway between uh uh Dartmouth and Harvard or it’ll get right to our airport get put in a plane delivered to any uh transplant surgeon in the country uh and hopefully uh we will eliminate the now multi-year backlog for people waiting for organs how many by the way the FDA in in a surprise in a surprise we told them we’re building this thing to do life support systems for this we showed them what this thing is they sent back a note to us we’re giving this product what they call breakthrough status so that they can accelerate the review of it so that we can start supplying these things even to today’s organs so we don’t lose so this is the challenge of when you get home and you start telling your loved ones and your business partners and your employees and so forth about
[00:27:01] this facility New Hampshire that’s manufacturing organs based on your individual DNA and this an Incredible World we’re living in buddy now let me just ask you got your PhD in cellular physiology and your medical degree from where I I forgotten so you should know and I think we got video of this when I am at the White House when we they asked us to come down the president you know to announce that they’re excited so excited to give out the first ever $80 million to a engineering organization to make this practical I’m at the podium and I I said just for the record everybody I know nothing about the magic goo that’s being made by all these universities I’m not a biologist I’m not a biochemist and whether whether that petri dish is full of Grandma’s Chicken Soup big molecules small molecules biologic don’t know but we know how to move it measure it control it we know how to monitor we we
[00:28:00] will figure out how to bring the engineering discipline to the scientists and if they can deliver the recipe for what they’re doing we will take their Artisan approach of being able to do this very expensively very unrealistically in terms of Quality Systems and we will bring it to scale so I have no PhD and any such thing I I I just want to point out that the majority of individuals who who have changed the world uh are coming with a clean sheet of paper and no preconceptions right and that helps you because if you start with the system that you now have your natural tendency is to incrementally make it a little better which is a pretty good thing we live in a world where you’d all like the things that you’re comfortable with to get a little bit better next year but when there’s gaping missing things using standard technology to eventually get there is is a Fool’s errand I mean they
[00:29:00] you know the light bulb was not an incremental improvement over a candle I could not have said it better everybody I want to take a short break from our episode to talk about a company that’s very important to me and could actually save your life or the life of someone that you love company is called Fountain life and it’s a company I started years ago with Tony Robins and a group of very talented Physicians you know most of us don’t actually know what’s going on on inside our body we’re all optimists until that day when you have a pain in your side you go to the physician or the emergency room and they say listen I’m sorry to tell you this but you have this stage three or four going on and you know it didn’t start that morning it probably was a problem that’s been going on for some time but because we never look we don’t find out so what we built at Fountain life was the world’s most advanced diagnostic Centers we have four across the us today and we’re building 20 around the world
[00:30:01] these centers give you a full body MRI a brain a brain vasculature an AI enabled coronary CT looking for soft plaque dexa scan a Grail blood cancer test a full executive blood workup it’s the most advanced workup you’ll ever receive 150 GB of data that then go to our AIS and our physicians to find any disease at the very beginning when it’s solvable you’re going to find out eventually might as well find out when you can take action Fountain life also has an entire side of Therapeutics we look around the world for the most Advanced Therapeutics that can add 10 20 healthy years to your life and we provide them to you at our centers so if this is of interest to you please go and check it out go to fountainlife decomp when Tony and I wrote Our New York Times bestseller life force we had $3,000 people reached out to us for
[00:31:00] Fountain life memberships if you go to Fountain life.com Peter we’ll put you to the top of the list really it’s something that is um for me one of the most important things I offer my entire family the CEOs of my companies my friends it’s a chance to really add decades onto our healthy lifespans go to Fountain life.com back/ Peter it’s one of the most important things I can offer to you as one of my listeners all right let’s go back to our episode all right so please hold that moonshot in your mind it’s one of the 100 or so but we one of the three we’re going to feature it right now um the second one is uh got a beautiful name called Daisy so Daisy some of you might remember that a few years ago we had this pandemic and again I know nothing about magic goo I don’t know why Spike proteins I don’t that’s not what we do I’ve got now at about a thousand Engineers but they’re
[00:32:00] mechanical engineers electrical engineers systems Engineers controls Engineers Plastics Engineers I got mathematicians I do computational fluid D we got a lot of really smart people we don’t play with magic goo by the way is Daisy off the record for the group can people talk about this tweet about this record it fine you may now yes you couldn’t last time we showed this to you in fact I may stick one on you right now so it turns out it turns out that in the midst of hearing that a couple of major companies including you know little guys like fiser and maderna uh were working on vaccines it became clear that they were probably going to get there again it’s a testament to how fantastic science has become but once they got there it was pretty well known that Holy marckel we’re going to need just for Americans alone three or 400 million doses for the world 8 billion Doses and the manufacturing capability even for those big guys isn’t going to be there not not only is that a problem but you need 8 billion
[00:33:01] syringes they’ll be fill in the ocean polypropylene you need 8 billion little 24 25 26 gauge hypothermic needles hard to make and hard to get rid of and they Ed from the various purpos glass Files full of this stuff and by the way you then need trained clinicians to deliver this stuff and even in this country we were being choked what are you going to do around the rest of the the world particularly developing world but we were told and it turned out that if you do a little research it’s true that it’s been known for more than 50 years that’s why I said incrementalism doesn’t work it’s been known for more than 50 years that vaccines in particular are way more effective if they’re delivered intradermally into your skin not through your skin and to this day the only legal way to read the label copy the only way to give a vaccine like most other things is either intramuscular deepen into your muscle intravenous or subcutaneous you
[00:34:01] poke through your skin and it goes into the interstitial space and gets absorbed why because your Skin’s so damn thin not even the best surgeon in the world’s going to be able to take a needle push it in but not through your skin and then deliver the dose it would be like telling all of you I have my liver and my kidney my lung and my pancreas they’re all in a pouch my paranal and I put it all in a balloon and put some fluid around it so they can float around in the balloon then you go to somebody and say take this needle push it into the wall of the balloon but don’t pop the balloon and then deliver into the balloon a little what the medical people call a little BB well it turns out and it’s the mechanism of action is apparently well understood by people in a clinical space that the reason you’d love to deliver a vaccine into the skin and not through the skin is because Nature’s pretty clever and your body has cells whose sole function is to warn your body make antibodies
[00:35:01] there’s something bad that’s gotten into you well if you put the cells that are going to tell your body to start making antibodies in your liver or kidney or heart or lung it’s a little late it would be like having a parachute that automatically opens on impact so so so what nature did is it said your skin your skin which is the largest organ in your body by weight other than bone your skin has 100,000 times higher density of these dendritic cells than any other organ in your body so we said why don’t we just come up with a simple way to put the vaccine directly into not through your skin turns out you’ll need less than one/ tenth the dose so if fizer could make 100 million Doses and you need one cc well now that’ll do a billion doses because you need a tenth as much there’s no pain there’s no side effects you wouldn’t need a professional
[00:36:01] to to make the delivery it has all sorts of advantages you can ship it around easily you don’t have waste like syringes and needles so we set out to do that and it turned out we there was a company an Israeli company that had pointed the right way they were using semiconductor technology to make the world I have the best machine shop in the world and the best plastic molders we couldn’t possibly make needles 500 million 7 in Long so sharp that they you put them on your skin and you can’t even really feel it penetrating the stratum corium but semiconductor technology can do it put up a picture here and I’ll show you a wafer which is a semiconductor wafer that has these micro needles on it and on this single W for the 75,000 of them that waer there is the same comes off the same machine that makes your processes your memory there’s a blow up diagrammatically next to it the hole in that thing is 100 million of an inch in diameter the length of it it is so sharp it’ll easily pierce your skin so we we
[00:37:01] developed this but we said and I’m sure you all remember poo equation that says that the flow through a cylindrical cross-section varies as the inverse fourth power of the well it turns out that to push any fluid through this thing is going to take a lot of time and nobody’s going to stand there and do it also a baby’s nice soft skinned or a young woman’s nice soft fleshy skinned and my old crudy leathery skin are so different how are you going to do it you need to eliminate technique so we we made a thing called Daisy we made a thing that looks like the Petals of a daisy it’s got a Band-Aid piece on the bottom of it if you push it down on your skin the first thing that happens is the daisy petals stretch they go flat like take an orange peel well as they go flat they become like a drum head for the skin underneath which which makes by the time you push hard enough you you’re directly against the skin with these sharp needles then there’s a tiny little BLB there’s there’s a basically about the size of a baby aspirin volume of
[00:38:01] space on the top side and when you push hard enough essentially to trigger this thing a little spring in there will put about two pounds of pressure on it so even though it takes two minutes to deliver this tiny tiny amount of drug nobody has to stand there for two minutes with a needle and a syringe poke in your arm so you know it was simple it only had about 20 parts we had it design develop manufactur do the injection molding the tooling anyway there’s a video of this uh we did our own in-house this one we don’t have to tell the FDA about we did our own little in-house study all we delivered was one tenth of a cc of saline to see that we get a nice BB and I did a cross-section un fortunate at De I have some of my employees are young right out of school some are gers like me some are men some are women some are Asian some are African let’s play this video so we we made some of these things we did all the tooling and we call it Daisy for the obvious reason now we did
[00:39:00] this little hokey thing cuz I figured I better take this thing to the FDA and tell them what’s coming um these are people inside my company uh he’s one of my Engineers that’s his actual child um we didn’t get a release from his child but um um uh he’s now only using the alcohol because we wanted to show you know makes the Band-Aid stick you really can’t feel those needles it feels like you just press a piece of sandpaper on your skin now yes it worked on that little girl and these are all a bunch of different uh uh people inside uh Deca now we’re going to do a A Time release there we’re going to wait two minutes and each of these people pulls it off to demonstrate that that device during that 2 minutes delivered a tenth of a cc there’s the BLB there’s the BB there’s the BB there’s a BB everywhere so we took this to a couple of big drug companies unfortunately we’ll probably do all the clinicals outside the US we’ve been that
[00:40:01] was your alternate name for the device the blub right yeah anyway uh we are now at a point where we have three or four major credible Pharma companies that realize this could be used for D fever and lots of other things in the developing world we are in the process of organizing a various set of clinical trials for that but I’m hoping by the next time a pandemic hits this country you won’t have to see syringes and needles and large volumes and get fevers and muscle all the side effects go away and we’ll have a we were told by the way by the clinicians many of them who graduated medical school probably long before you said we haven’t seen a new method of delivering a drug into a person since they developed the needle which was essentially during the Civil War anyway we’re very proud of that thing and we’ll see how it goes did you see the movie Oppenheimer if you
[00:41:00] did did you know that besides building the atomic bomb at Los Alamos National Labs that they spent billions on biod defense weapons the ability to accurately detect viruses and microbes by reading their RNA well a company called viome exclusively licensed the technology from Los Alamos labs to build a platform that can measure your microbiome and the RNA in your blood now viome has a product that I’ve personally used for years called full body intelligence which collects a few drops of your blood spit and stool and can tell you so much about your health they’ve tested over 700,000 individuals and used their AI models to deliver members critical Health guidance like what foods you should eat what foods you shouldn’t eat as well as your supplements and probiotics your biological age and other deep Health insights and the results of the recommendations are nothing short of Stellar you know as reported in the American Journal of Lifestyle medicine after just 6 months of following vom’s
[00:42:00] recommendations members reported the following a 36% reduction in depression a 40% reduction in anxiety a 30% reduction in diabetes and a 48% reduction in IBS listen I’ve been using viome for 3 years I know that my oral and gut health is one of my highest priorities best of all viome is Affordable which is part of my mission to democratize health if you want to join me on this journey go to vom.com Peter I’ve asked naven Jane a friend of mine who’s the founder and CEO of viome to give my listeners a special discount you’ll find it at vom.com Peter all right your third moonshot and then we’re going to go to your questions um a subject near and dear to your heart and I remind everybody the first time you and I ever met in your office in New Hampshire the conversation was very clear I was there pitching in my next prize before I had met anua had this
[00:43:00] idea for this prize wanted to do space flight I had some people tell me you got to meet Dean Cayman he’s amazing and he said Peter let me make this very clear there’s one one organization that has priority in my life above everything else and that is first and as long as you support first and what I do in first then I’m happy to support you and um I am happy that I and my family have been able to hold true to that and uh and that you have been an extraordinary support for ex prise and abundance so let’s talk about first so I am here to talk about first and all of you should know uh I am unabashedly I will gravel I will beg I will scream I will threaten I don’t care
[00:44:00] um I think this planet of ours is in a race to develop enough technical competence across now 8 billion people soon probably more we’re in a race between staying at least one step ahead of catastrophy through better technology or losing the race to a global catastrophe man-made or otherwise and I wouldn’t be confident if I all of you don’t worry we’ll win that race um I’ve learned over the 32 years now of trying to build first that there are actually very very very few people when you look at the denominator being8 billion that are either going to make that happen or not and I’d like to say I don’t want to embarrass him but I want to embarrass him um I would tell you the reason I’ve never turned Peter down when he’s asked me to do
[00:45:00] these things is I always think I get more out of it than he does I almost feel guilty about it sometimes but not to stop but but I also used to ask myself all the time how does Peter year after year create a bigger more incredible group of people that he can put in one room that that do what they and I know I’ve told you this year after year it’s a I don’t know how he does it but in listening today and after you played that thing last night with uh do it my way it occurred to me Peter and think about this a second people are mostly driven not in their day job but their passion whether it’s religion or by being part of a group that shares an idea and as I listen to everybody over the last day or I realize what Peter’s magic is is he’s figured out how out of
[00:46:01] the 8 billion people to find a very very small group of people and it is small that shares three important characteristics that makes that group even smaller because it’s the vend diagram of people that have a lot of resources and you know you find people with a lot of resources and you’ve introduced many to me and I thank you for that you introduced me to Martin rothblat to the guys that funded the entire Mexico I mean it goes on and on people with resources because people without resources get up every day they’re worried about whether they can feed their kids they don’t have the tools they don’t have the resources to change the world they have to deal with what they get but a lot of people have powerful resources most of them use it as a weapon not a tool they come into this world and if they have more resources they use it to take more out of the world he’s found the people that have resources and that for some reason he’s found the
[00:47:00] ones that want to put something back into the world that makes it an even smaller subset and then he I’m GNA stop I will just tell you I have a feeling that we ought to like give him some kind of title and I was thinking of that today and I think it’s like you you are like the pope of Hope no no no I I used to think I was going to I was going to stop my own organization moment I I I would you know I used to tell people you know they asked me am I religious I said yeah I belong to the holy order of the Sacred differential equation and and and and and you know people used to tell me you know love makes the world go round I said well actually it’s angular momentum but but but but I realize that if you’re going to get the world to do the right thing and
[00:48:01] if you’re going to find a way to get a lot of kids really smart you can’t just be analytic and academic and Technical you need to find people that have resources that are willing to come together that are willing to do something that will make the world a better place and he’s the only person I know that spends his life trying to collect these people and I’m just here to steer a few of them to help us so with that as background 32 years ago I started a not for-profit organization called first I called it first for inspiration and recognition of Science and Technology because I thought at the time that this country was totally misguided when all of our political leaders back then all of our business leaders all our education leaders thought the everybody knew we’re producing way too few scientists and engineers this country was going to lose its position which we’ve seen what’s happened now and they
[00:49:01] all said it’s an education crisis I’m a uh I’m an inventor right what do inventors do inventors look at the same problems as everybody else and see them differently my mom is a teacher and you know I would sit at home and say do you really think suddenly we have an education crisis in this country even back then 32 years ago we spent more money per capita on education public education in any country in the world I said it’s not an education crisis it’s a culture crisis and it’s not what we don’t have enough of schools textbooks it’s what we have too much of distractions and false Heroes and the only people that little kids 30 years ago and now at the interet it’s even worse the only superheroes they could name came from the NBA the NFL or Hollywood and in a free country where you get the best of what you celebrate we celebrate sports and entertainment which is why the US produces great Sports and great entertainment yeah physics and math and not so much so I said kids love sports let’s just turn
[00:50:01] physics and math and science into a sport I thought it would be easy we would do it a year of example people would see how much fun it is if you did it as an after school aspiration event just like football or Bas and I just thought this is a no-brainer and everybody will adopt it it’ll be as fun as any other sport but it’ll be the only sport where every kid on every team can turn pro so this is a good deal and it grew from 23 teams in year one to 50 to 100 to 200 cuz I needed mentors I needed superstars in my sport like baseball and football have them and Hollywood has them but we were reaching a point where I needed more media attention we needed more resources and he’s referring to a conversation I had with him at the time and I said Peter you have to help me get more awareness for first and he did and every year since we’ve worked together and it’s grown this year and everybody makes fun of me when I take out my little this year Mar Madness we’re in the middle of it the season got so big that instead of my one little card with
[00:51:02] the front being first and the back which was for the first five years come to Manchester with the 23 teams you now have to open it up and look at the schedule for 2024 and you see 182 cities holding events for 82,000 schools with 82,000 schools with 200,000 volunteer mentors we gave at $80 million in scholarship down on on uh scholarship Pro last year at the championship in Houston where it will be this year from the 17th to the 20th of April um it’s an incredible collection of passionate parents Teachers Community leaders every one of the Fortune 500 tech companies is a big sponsor and I’m going to show a quick video of what we did to get first thank you sir up bigger and better and I really thank you for giving me this opportunity because you’re all going to end up with homework in a couple of minutes out of
[00:52:00] this but what happened was after about 25 years of running first because almost every big company is multinational I would go to the Championships and there’d be teams from 40 or 50 countries and that’s because you know the big companies were uh uh they’re International so they would send the kits around I ended up being in Israel at one point and before he passed with Shimon Perez and by then there were 500 or 600 teams in Israel and by the way the Palestinians is they’re all working together he then says to me it’s not good enough that after 25 years you only have 40 or 50 countries Dean this should be an international sport like the Olympics and every country in the world needs to participate under the condition that he agreed to be my honorary chair I founded a a sister organization to first called first Global and I said I’m going to get one
[00:53:00] team from every country in the world I thought that’s a modest goal 54 countries in Africa one team per country 24 countries in the Middle East one team and I’m going to show a quick uh um um set of pictures but besides first as I just told you being on a on a tear in this country and by the way uh somebody give me my little kit quick um year after year I’ve said we ought to have first in every school in the United States it’s a cheaper sport than football or basketball you have less likelihood of breaking your knees or necks let’s let’s make this in every school finally over the last year I was able to work internally to create kits where for less than $100 we can build a very sophisticated process and I went to our governor in New Hampshire and when I told him what we could build a robot kit for the governor of New Hampshire and this is public now and you’ll see it said Dean you’ve been beating on us for years to
[00:54:00] make it a standardized sport like the others if you can give us a kit like that with the curriculum to go with it and kids love building things like this he said it’s under a hundred bucks for you to build it I said yeah we’ll give them to you at whatever they cost the governor of New Hampshire said we’re not going to put a first team in every school we’re going to put a first kit in every classroom in the state and we did it this year this kit costs less than a typical textbook and kids don’t even open textbooks they’re not relevant but they do Hardware they do software they do development they work in teams and knowing that you’ve got little kids you now have a first robot kit and we’re going to be trying to get other Governors to make this a standardized national sport but back to First Global and by the way let me just ask you guys as we’re going through this uh please post your questions and upvote questions in the in the app if you would if you’ve got questions popping up in your head I just want to make sure I get us out of
[00:55:01] here on time for the party and I can never stop Dean from talking about first so so so after after sadly he passed away a year before that but I said let’s invite every country in the world to send one team and I figured we better do the first one in the US because I needed support and I thought I’d get 30 or 40 countries I got 136 I was desperate I rent red I rented Constitution Hall in Washington and we had 136 country countries there the following year next slide we said we’re moving it’s an international thing like the Olympics that has to move every year we went to Mexico City there it is we had 166 countries and on that stage is a nanari by the way who’s helped us every year the following year we didn’t have 166 countries we went to Dubai the belly of the global Beast the Middle East and we made a deal with the royal family that every country in the world’s going
[00:56:00] to be invited and treated well and so all 24 countries in the Middle East including Israel is in that Arena we had 191 country we had 190 countries but 191 teams because one team from Afghanistan to Zimbabwe we’d always line them up alphabetically for opening ceremonies like the Olympics they and as the guy is reading from the gets to the ages Haiti and Hong Kong Honduras he reads Team Hope and a bunch of kids walk across the stage with their flag but their flag was our first logo and he’s reading that this is team hope these students have no country they grew up in a refugee camp in Syria they have no country but they have hope so they are Team Hope and they’ve been with us every year so it gets better it gets better we had a couple of years of Co and then the the year that we came back which is a year and a half ago now we said let’s go to a safe place
[00:57:01] to restart so we went to Geneva a place that convenes the world so we did that and at the end of that event I always feel compelled to remind people it’s not about the robots it’s about bringing the world together it’s about important things so I’m standing on this stage and you’ll see why this is important in Geneva and I’m looking out at 190 flags being waved and I said hey everybody we just finished a great time you’ve proven that you all know how to get along with each other sharing Parts sharing ideas teaching each other you’re way better than your parents and grandparents uh but maybe you’ll break this NeverEnding cycle but I said for next year just to remind everybody we’re not about the robots I’m going to ask you to sign two what I think are necessary International agreements and I said I’m an American and I’m proud of being an American but I am not going to you know force on any other country my background or Heritage
[00:58:00] or Traditions but we need something that will be a complement to two documents that I grew up with in America one is the Declaration of Independence and we collectively with 190 countries by the way I said we need to recognize that while you all need in your country to have your Independence and diversity and your language and your culture keep it all and be proud of it all but your generation’s growing up in a world where pandemic don’t stop at the end of an arbitrary line go look at what NASA’s picked and and and global warming affects everybody no matter where you created the mess so I said your generation is going to grow up with a declaration of interdependence and those things that you need to share and support you’re all going to agree to do or we’re not going to do this again I said there’s another document we have in America that I really grew up with and appreciate and it’s the Bill of Rights and I hope in your own countries whatever is an appropriate set of Rights that you’re willing to protect and you should do that but in our ever more
[00:59:01] intense global environment you’re all going to grow up in a generation that needs a bill of responsibilities and you need to be responsible to know the truth and speak the truth and respect the truth and respect each other even when you you differ so between now and next year we’re going to make two documents a declaration of interdependence and a bill of responsibilities and it will be a universal a pair of documents that every country every team is going to sign or they can’t participate in first Global I did not know at the time that one year later we would start the 2023 event in Singapore I flew for 22 hours I got there everybody’s excited I go to the arena the night before I’m looking at them setting up for opening ceremonies on October 6th the following morning October 7th I’m watching as opening ceremony starts and
[01:00:00] alphabetically these teams are walking across the stage including Iran Iraq and Israel and my phone is lit up Hamas invades Israel and is it fate Pete Peter all I know is I was in a room much bigger than this with kids from every country in the world communicating cooperating and working together looking at BBC telling us that the world is about to go into its worst self-destructive mode since World War II for the next three days we had our event and by the end of the third day I was sure I had made giant like tablets of those two documents and lines with typewritten Afghanistan to Zimbabwe under 191 and I told every team not knowing what was happening on the evening of the 6 when we set it up on the morning of the 7th I saidou all going to have to sign on these we’ve agreed over the internet all year well by the third day I got there on the 10th the global news
[01:01:00] was horrific but you’d go in and you could feel the energy and the support and the cooperation we started closing ceremonies in Singapore I was so afraid I’d walk out and I would see some any one group anyone would have destroyed those tablets or would have put graffiti on them or worse I walked out people and every single line every country had a signature in it and I said to the people there pack these things up and protect them and send them back to me I don’t know if I’m going to deliver them to the United Nations no they’re dysfunctional I’ll bring it to Washington I’ll no I now have them in the lobby of my building maybe I’ll give them to the Institute of Peace but I want you to I this is closing ceremonies and I can give you all copies those four tablets are the Declarations of interdependence and the Bill of responsibilities and there are 191 signatures on them now now we took we took a lot of the videos
[01:02:01] of what was going on the only b-roll you’re now going to see in a one minute piece the only b-roll we had or that you’ll see here is just from this season it’s it’s what was going on during the world’s worst version of self-inflicted wounds and I remembered that one of my big sponsors and you know this Coca-Cola mutar Kent joined the board they’re the biggest sponsor of sporting events in the world and I told them I’ll build his little freestyle machines for him if he joins my board and I built him 50,000 of his machines and he joined the board and and I remembered some of you probably are old enough all of that Coca-Cola during probably 30 years ago one of their ad Jingles whatever they are was a song called I want to Teach the World to Sing in Perfect Harmony and that refrain was finished with Coke the real thing and I thought I had images again of the way they did that showing groups of kids on mountaintops you probably remember that
[01:03:01] of course and I said no wonder they’re a great marketing company after 30 years kids can’t tell you what the law of cosign is but they’ll remember that song okay so so I said to myself we’re going to take that song I figured I’ll go back to them nicely and say yeah anyway I said let’s take that song let’s write a few new words for it like instead of coke the real thing first Global the real dream and instead of you know it’ll be how to innovate and I said we just have to change the words a little don’t change the tune don’t change the music at all and with no professional people behind it our little group made the following one minute piece and I want you to see this and look at the background look at the kids and look at their their their emotion and their attitude and their energy this is between October 7th and October 10th of last year I’d like to see the world unite around a
[01:04:01] global Lane grow empathies and leges and work as one in name I’d Like to Teach the World to build in Perfect Harmony to and innovate as one community I’d Like to Teach the World to lead in solidity to shape our future ever bright as one Community that’s the real dream what the world needs today the first Global dream take us stand today that’s the real dream [Applause] [01:05:06] [Music] as Margaret me very famously said never doubt that a small group of dedicated people will change the world that’s normally the all they quote the next line is the important piece she finished it by saying that’s the only that ever a will big entrenched institutions have neither the capability vision or the incentive to change if you’re fat dumb and happy on top you want the status quo the world’s a mess and if all of you are going to sit back and hope that the politicians are going to fix it have you looked around lately again I’m not trying to flatter this man but he’s brought people together and I will tell you the third one it’s not just resources and and people that want to give instead of take
[01:06:00] from the world but we need people with vision and courage and if you look at the I don’t know how he does it but he’s created this tribe and I hope you support lots of other things collectively but some of them are businesses and they’ll go and but what I’m really hoping is each time he’s invited me to be here I’ve Come Away with a few and sometimes more than a few people that are willing to say I’m going back to my country or my organization or and I’m going to find a way to help you do this and I think if a small group like this is now big enough to measurably change the trajectory of the Global Connection of the next generation of kids imagine every kid on every one of those teams has stayed connected to all 191 of them in a relatively short time 10 15 20 years these kids are going to be running the world they can do it collectively using technology as a tool or they can
[01:07:02] do it the way Generations before them have in their own tribes fighting with each other competing with each other and destroying each other you guys ought to help us make first Global a bigger Global event than the Olympics it’s more cost effective it’s more fun it’s easier to do and on April 11th of this year which is coming up we’re announcing where it will be next year it’s a spectacular City we’re announcing what the theme will be and you’ve covered it with a couple of your speakers so well it’s unbelievable we did energy we did water when you see the theme you’re all invited we’re going to be at the Meridian House in Washington DC we have the senior senators from the Republican side speaking the senior senators from the Democratic side speaking the guy in the middle speaking and uh Secretary of Commerce it’s going to be a great celebration it’s going to
[01:08:00] be a great unveiling that’s April 11th you’re all invited and then the event will be three days we’ll announce what city it will be in and what country it will be in but sketching right now it will happen between September 26th and September 29th at the end of this year and if you come and you bring your family and you bring your friends it will be the most hope ful thing you’ve done in a long time I invite you all to [Applause] participate we’ve talked about this so many times do you believe that our schools your schools that you entrust to your kids education and is preparing them for the future there’s only one place that I know it’s even scratching the surface of that uh and that is first um it’s an incredible Vision
[01:09:03] incredible passion Dean that you’ve given this uh it’s worthy of a Nobel Peace Prize in the final result honestly um but there is there yeah but there is there’s there’s no other institution that has a hope of scaling with this message what is it doing it’s teaching collaboration between kids and it’s teaching that technology is a tool of collaboration uh let me ask how many of you here uh are currently supporters of first would you please stand up please stand up please stand up I know we have a few individuals here that are supporting on a national level and dozens of schools I know my family has been supporters of first now for a multitude of
[01:10:00] years uh I will ask you above everything else consider supporting a a school it’s about 10K in this country yeah and by the way for those of you that didn’t stand up I don’t want you to feel guilty I’m good at throwing guilt ball my mom’s a Jewish mother but but but you need to know I feel guilty because after 32 years I know there’s only two kinds of people in this country the ones that know about first and love it and the ones that have never heard of it so how can I blame them and that’s why I come to this guy because he’s got the best megaphone and the best bright light no it’s just it’s my job here is to present to you extraordinary technology and this is an extraordinary social technology uh there are very few things that spread a wave of of calming sentience and Mission and
[01:11:00] purpose um and by the way if anybody doubts that putting one team in each new country after 25 years we only had 40 in the first year first Global we had all 54 countries in Africa little Rwanda had a country had one team this is 2018 this year internal to Rwanda they had to do a playoff which is what school is going to represent them at first Global because Rwanda now has internal the way we have first in this country Rwanda has 500 teams turkey has a th000 teams Poland has 500 teams braz we we are spreading this thing but I’m doing at Grassroots people I don’t have sales marketing expertise we need the resources the expertise the passion The Village the people in this room we need consider a school consider a country if you’re a company get involved I can’t think of
[01:12:02] something that has greater decadal long impact but ladies and gentlemen for a man who has transformed so many Industries and is transforming our future more than any single human being for me the two greatest heroes on the planet it’s Dean and Elon and let’s give it up for the amazing Dean Cayman [Music]