Weekly Dose of Optimism #180

Curation covering AI drug discovery, frontier AI models, autonomous shipbuilding, origin of life research, and education reform.

Curated Topics

1. IsoDDE (Isomorphic Labs) -- AI drug design engine doubles AlphaFold3 accuracy on hard structures; finds hidden druggable pockets from amino acid sequences alone; compresses search from months to minutes
2. Gemini 3 Deep Think -- 84.6% on ARC-AGI-2 (next closest: 68.8%); helped solve Erdos conjectures; assisted materials science research at Duke; caught logical flaw in peer-reviewed proof
3. Blue Water Liberty Class -- 190-foot autonomous steel ship for US Navy; privately funded; targeting 10-20 vessels/year serial production
4. Origin of Life (QT45) -- 45-nucleotide ribozyme that can synthesize itself and its complement; may explain how self-replication began; triplet code matches modern genetic code
5. Texas School Choice -- 42,000 families applied day one for Education Freedom Accounts; Odyssey (Not Boring Capital portfolio) running operations

RDCO-Relevant Items

• IsoDDE: AI compressing search phases mirrors data engineering pattern of replacing manual exploration with systematic computation
• Gemini 3 Deep Think: cross-domain reasoning capabilities relevant to research agent design