Zepbound (tirzepatide) — dose & response log
Running log, newest entry first. Founder's plan: 2.5 mg week 1 → 5 mg week 2 (script starts at 5; he chose a one-week ease-in). Prescriber: his nephrologist (gout-aware). Shot day: Thursday (first dose Thu afternoon → side-effect peak window Fri-Sat). Targets: 202 → 180 lbs; protein ~150-180 g/day; water 2.5-3 L/day (gout prophylaxis — dehydration is his flare trigger and GLP-1s suppress thirst).
Watch items each week: weight, appetite shift, nausea/GI, reflux (GLP-1 delayed gastric emptying can transiently worsen it — track against [[2026-05-29-nocturnal-reflux-episode-log]]), hydration discipline, any gout twinge (early-flare signs = escalate hydration immediately).
Entries
Dose 1 — 2026-06-11 (Thu), 2.5 mg
- Taken ~3:49 pm ET (founder iMessage). Injection site not reported.
- Baseline weight: 203.4 lbs (founder weigh-in, same day as dose 1). Delta to 180 target: 23.4 lbs (~11.5%). Prior reference: 202 lbs (2026-05-21).
- Pre-dose state: no active gout flare reported; reflux baseline per the 5/29 episode log.
- Coaching delivered: front-load water 72h, protein-first when appetite dims, smaller meals + nothing within ~3h of lying down days 1-2 (reflux guard).
Related
- [[2026-05-21-founder-health-assessment-v1]] — baseline picture
- [[2026-05-29-nocturnal-reflux-episode-log]] — reflux instrument for the early-weeks watch
- [[2026-05-22-nutrition-plan-v1]] · [[2026-05-22-workout-plan-v1]] — protein + resistance-training side of muscle preservation
- Memory:
user_health_clinical.md(tirzepatide section)